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ea0090oc7.3 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

The mesenchymal stem cells induce immunosuppressive microenvironment in pituitary tumors

Marrero-Rodriguez Daniel , Taniguchi Keiko , A Cortes-Morales Victor , Valenzuela-Perez Alejandra , Vela-Patino Sandra , Cano-Zaragoza Amayrani , Martinez Florencia , Kerbel Jacobo , Andonegui-Elguera Sergio , Gomez-Apo Erick , Chavez-Macias Laura , Montesinos Juan Jose , Mercado Moises

The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells. MSC are a subset of heterogeneous cell populations characterized by the expression of CD105, CD73, and CD90 that can differentiate into chondrocytes, osteoblasts, and adipocytes in vitro. They are known to have immunomodulatory capabilities. Our aim was to isolate and characterize the immunomodulatory capabilities of MSC from pituitary tumors (P...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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